New Horizons in Diabetology

The prevalence of diabetes has alarmingly increased in both developed and developing countries all across the world in the recent years. The prevalence of different complications and comorbid conditions associated with diabetes is also rampantly increasing, thereby negatively affecting lives of many people. In fact, obesity which is associated with diabetes is considered as a major public health concern in many countries. Nevertheless, it can be argued that still more progress is to be made in different fields of prevention, diagnosis, and treatment of diabetes. This gap in the science of Diabetology, arguably, stems from insufficient synchronized interdisciplinary basic and clinical research in the field. This deficiency may be addressed through finding the gaps in the published literature by means of plotting different diabetes maps and focusing research on them to promote the concept of translational medicine. Lack of comprehensive diabetes research maps and the scarcity of the literature in the related interdisciplinary fields can be considered as major hindrance to the future advancement of the science of Diabetology. With this view, we conceived the concept of publication of a special issue on the subject and invited authors to submit any original research or review paper with the potential of opening new horizons to prevention, screening, and treatment of diabetes. Out of approximately 50 manuscripts submitted, in this special issue, 15 articles have been approved by reviewers to be published on a wide range of relevant basic and clinical subjects. In the field of screening for diabetes, findings of a study by S. M. Joyce-Tan et al. demonstrated that genetic variants of the RAS can modestly influence the risk of type 2 diabetes. P. Haghvirdizadeh et al., in a different study, reported that R219K polymorphism of ABCA1 gene could be considered as a genetic risk factor for type 2 diabetes among certain populations. In another article, M. Khodaeian et al. assert that genome wide association studies on large number of samples can be helpful in the identification of diabetes susceptible genes and may be used as an alternative to studying individual candidate genes which is a time-consuming and expensive method. In a different article, P. Haghvirdizadeh et al. findings provide evidence for the contribution of common KCNJ11 genetic variants to the development of DM. In regard to the underlying mechanisms of diabetes and its complications, M. Káplár et al., in an original research article , demonstrated a dual role for …